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tumor regression
In vitro study of CI-994
The STAT3 inhibitor NSC 74859 is effective in hepatocellular cancers with disrupted TGF-β signaling
2(4):401-8
ML323 - USP1-UAF1 Inhibitor. CAS# 1572414-83-5 size:2 mg solid tumor regressionML323, CAS No. 1572414 83 5, is a potent, selective and reversible inhibitor of the USP1 UAF1 deubiquitinase complex with IC50 ~76 nM in the Ub Rho assay. It has excellent selectivity against human DUBs, deSUMOylase, deneddylase and unrelated proteases, showed little to no inhibition against other USPs tested, including USP2, USP5, USP7, USP8, USP10, USP11, USP14 and USP21. Inhibition mechanism and HDX studies suggest that ML323 binds away from the
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