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[15] Contraindications [edit] Contraindications for NPWT use include: [16] Malignancy in the wound Untreated osteomyelitis Non enteric and unexplored fistulas Necrotic tissue with eschar present Exposed blood vessels, anastomotic sites, organs and nerves in the periwound area (must avoid direct foam contact with these structures) [17] Effectiveness [edit] Negative pressure wound therapy is usually used with chronic wounds or wounds that are expected to present difficulties while healing (such as those associated with diabetes)