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InChiKey: GJFCSAPFHAXMSF-UXBLZVDNSA-N
Smiles: NC1N=C(COC(=O)C2C=CC(=CC=2)[N+]([O-])=O)N=C(NC2C=CC=CC=2)N=1
Acalabrutinib demonstrates on-target effects including decreased phosphorylation of PLCγ2
PluriSln-1
Furamidine dihydrochloride - PRMT1 Inhibitor. CAS# 55368-40-6 0113 InChiKey: GJFCSAPFHAXMSF-UXBLZVDNSA-NFuramidine, CAS No. 55368 40 6, is a potent, selective and cell permeable Protein arginine methyltransferase 1 (PRMT1) inhibitor with IC50 of 9. 4 M. It has >10 fold selectivity PRMT5, PRMT6 and CARM1 (IC50 are 166, 283 and >400 M respectively). It targets the enzyme active site and is primarily competitive with the substrate and noncompetitive toward the cofactor. Furamidine effectively inhibits intracellular PRMT1 activity and blocks cell
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