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ABT-594 is orally active
Timosaponin AIII is identified as a major selective cytotoxic activity in BN108
InChiKey: AWARIMYXKAIIGO-FIIMHDCBSA-N
It binds to the Smo receptor (Kd = 12 nM) and inhibits binding of the Smo receptor agonist SAG-1
BMS 599626 dihydrochloride Catalog No.:M23416-C ABT-594 is orally activeBMS 599626 dihydrochloride is a potent and selective inhibitor of EGFR and ErbB2 with IC50 values of 22 and 32 nM, respectively . The epidermal growth factor receptor (EGFR) is the cell surface receptor for epidermal growth factor and plays an important role in tumor invasion and cancer cell proliferation. Receptor tyrosine protein kinase erbB 2 (ErbB2) is a human epidermal growth factor receptor and plays a critical role in breast cancer. BMS 599626
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