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CVT-10216 - CAS# 1005334-57-5 Catalog No.:M6674-2 CN(C)C1C=C[N+](CC2C=CC(=CC=2)OCCOC2C=CC(C[N+]3C=CC(=CC=3)N(C)C)=CC=2)=CC=1

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CN(C)C1C=C[N+](CC2C=CC(=CC=2)OCCOC2C=CC(C[N+]3C=CC(=CC=3)N(C)C)=CC=2)=CC=1

especially in a tumor microenvironment

Raleigh MJ

6-dimethyl-5

CVT-10216 - CAS# 1005334-57-5 Catalog No.:M6674-2 CN(C)C1C=C[N+](CC2C=CC(=CC=2)OCCOC2C=CC(C[N+]3C=CC(=CC=3)N(C)C)=CC=2)=CC=1CVT 10216, CAS No. 1005334 57 5, is a Potent and selective, reversible inhibitor of aldehyde dehydrogenase 2 (ALDH2) (IC50 values are 29 and 1300 nM for ALDH2 and ALDH1, respectively). CVT 10216 increases acetaldehyde after alcohol gavage and inhibits 2 bottle choice alcohol intake in heavy drinking rodents, including deprivation induced drinking. Moreover, CVT 10216 also prevents operant self administration and eliminates cue induced reinstatement of

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