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AG-636 217903 5-dihydroxy-4-methoxy-6-methyloxan-2-yl]oxy}-3-iodo-5

SKU: 2386378681

4.3
USD120.00 USD169.00

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Description

5-dihydroxy-4-methoxy-6-methyloxan-2-yl]oxy}-3-iodo-5

In vitro: Dilute the received ready-to-use iPSC-TSPC cocktail at 1:1000 into your iPSC reprogramming medium to make the iPSC-TSPC media for iPSC induction

9 μM are obtained after 1 day of treatment with Reserpine hydrochloride in JB6 P+ and HepG2-C8 cells

when administered by oral gavage in water once daily beginning at the time of the first collagen immunization

AG-636 217903 5-dihydroxy-4-methoxy-6-methyloxan-2-yl]oxy}-3-iodo-5AG 636 is a potent, reversible, selective and orally active dihydroorotate dehydrogenase (DHODH) inhibitor with an IC50 of 17 nM. Differential AG 636 activity translated to the in vivo setting, with complete tumor regression observed in a lymphoma model. Dissection of the relationship between uridine availability and response to AG 636 revealed a divergent ability of lymphoma and solid tumor cell lines to survive and grow in the setting of depleted

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