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NVP-ADW742 was found to suppresse survival and resistance to chemotherapy in acute myeloid leukemia cells
Formula: C43H51N3O11
11 nM and 180 nM for PDE5
Molecular Weight: 817
CB-839 H 298 NVP-ADW742 was found to suppresseTelaglenastat, also known as CB 839, an is orally bioavailable inhibitor of glutaminase, with potential antineoplastic activity. Telaglenastat selectively and irreversibly inhibits glutaminase. By blocking glutamine utilization, proliferation in rapidly growing cells is impaired. Glutamine dependent tumors rely on the conversion of exogenous glutamine into glutamate and glutamate metabolites to both provide energy and generate building blocks for the
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