TH-302 - Hypoxia-activated Pro-drug. CAS# 918633-87-1 Catalog No.:M60089-2S 9(3):566-71

Name: TH-302 - Hypoxia-activated Pro-drug. CAS# 918633-87-1 Catalog No.:M60089-2S 9(3):566-71
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9(3):566-71

TH-302 - Hypoxia-activated Pro-drug. CAS# 918633-87-1 Catalog No.:M60089-2S 9(3):566-71TH 302, CAS No. 918633 87 1, is a highly potent and selective hypoxia activated pro drug targeting hypoxic regions of solid tumors with an IC50 of 19 nM. It is stable to liver microsomes. However, under hypoxic conditions, it is selectively and irreversibly converted to its active phosphoramidate based, DNA crosslinking, bis alkylator. TH 302 inhibits H460 cells and HT29 cells with IC90 of 0. 1 M and 0. 2 M, respectively. It shows much enhanced

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